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ea0086p199 | Metabolism, Obesity and Diabetes | SFEBES2022

Temporal periods of mild hyperglycaemia in pregnancies complicated by gestational diabetes and LGA alter placental transcriptomic networks associated with vascularisation and M2 hofbauer cell polarisation

Byford Abigail , Walsh Katy , Holder Beth , Scott Eleanor , Forbes Karen

Background: Gestational diabetes (GDM) leads to an increased risk of delivering large-for-gestational-age infants (LGA), which has been linked to altered placental vascular development. Women with GDM who deliver LGA infants have temporal periods of mild hyperglycaemia, detectable by continuous glucose monitoring (CGM), compared to women who deliver appropriate-for-gestational-age infants (AGA). This study aimed to assess the impact of physiological periods and levels of hyper...

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Endocrine Abstracts

Temporal periods of mild hyperglycaemia in pregnancies complicated by gestational diabetes and LGA alter placental transcriptomic networks associated with vascularisation and M2 hofbauer cell polarisation

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